Scientific Studies

Significance of Glutathione - "The Guardian of the Cell"

MASTER Anti-oxidant in each Cell
MASTER Anti-inflammatory in each Cell
MASTER Detoxifier inside each Cell
Primary Detoxifier of Heavy Metals
Chelator - 50% as effective as oral chelation in getting rid of Mercury
It transforms Hemoglobin into its reduced state, enabling it to accept oxygen and carry it to the cell
Major Protector of the Mitochondrial DNA (Power House of the Cell)
Major Protector of the nucleus of the cell and the DNA of the cell
Major Protector of the Immune Cell and the Immune System
Cardiovascular System Enhancer
Only Antioxidant that can recycle itself
First line of protection against environmental chemicals and toxins

Glutathione: Reference Links

Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation

https://pubmed.ncbi.nlm.nih.gov/33428377/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413479/

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402141/

https://pubmed.ncbi.nlm.nih.gov/11028671/

Mitochondrial Glutathione, a Key Survival Antioxidant

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821140/

Glutathione-coordinated metal complexes as substrates for cellular transporters

https://academic.oup.com/metallomics/article/13/5/mfab015/6189687?login=false

https://pubmed.ncbi.nlm.nih.gov/33549285/

https://pubmed.ncbi.nlm.nih.gov/23409922/

Reduced Glutathione: A Radioprotector or a Modulator of DNA-Repair Activity?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635210/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025786/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413479/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736736/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690269/

Benefits of N-acetyl cysteine (NAC)

NAC (N-acetyl cysteine) health benefits
Essential in helping the body replenish glutathione
Creating safe quercetin metabolites
Antioxidant that is used as an antidote for acetaminophen overdose
Reduce the formation of pro-inflammatory cytokines and mitigate the impact of cytokine storms in COVID-19
Helps breakdown of mucus in the respiratory tract
NAC with doxorubicin can be highly effective to reduce tumor formation and prevent metastases
Helping the liver and gallbladder deal with fats
Assisting regular cell death (a process known as apoptosis)
Anti aging and anti melanogenic effects

NAC: Reference Links

https://pubmed.ncbi.nlm.nih.gov/30892320/

https://www.lifestylematrix.com/blog/post/the-quercetin-paradox-the-secret-to-preventing-toxic-quercetin-metabolites

https://pubmed.ncbi.nlm.nih.gov/37575276/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995409/

Benefits of Quercetin

Quercetin can induce apoptosis and cell cycle arrest in different cancer cell lines such as those of breast, prostate, lung, and colon cancers.
Shields the body from free radicals
Demonstrated strong anti bacteria action against many bacterial species
Inhibits fungal growth by inducing oxidative stress and altering the cell membrane composition of fungi, leading to cell death.
Inhibiting acetylcholinesterase and protect against neurodegenerative in Alzheimer patients
Anti obesity as it inhibits adipocyte differentiation and adipogenesis, critical processes in causing obesity
Significantly inhibit both alpha amylase and alpha glucosidase activities concentration to reduce diabetes
Ability to enhance endothelial function which helps regulates blood pressure and prevents hypertension.
Has potent anti-inflammatory and antioxidant properties that suppresses the production of inflammatory cytokines in asthma patients

Quercetin: Reference Links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/

https://www.lifestylematrix.com/blog/post/the-quercetin-paradox-the-secret-to-preventing-toxic-quercetin-metabolites

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416724/#:~:text=This%20study%20demonstrated%20that%20Quercetin,migration%2C%20invasion%2C%20colorectal%20cancer

https://www.lifestylematrix.com/blog/post/the-quercetin-paradox-the-secret-to-preventing-toxic-quercetin-metabolites

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384403/

Benefits of Vitamin D and D3

A superhormone receptor that does positive transcriptional changes in the DNA
A receptor expressed in several brain structures to prevent multiple sclerosis, stroke, and Alzheimer’s and Parkinson’s diseases
Has protective role against SARS-CoV-2 infection and Covid-19 disease severity to increase mortality
Activates macrophages and production of antimicrobial peptides by epithelial and immune cells to eradicates bacterial or viral infections such as influenza
Low level of vitamin D is associated with an increased risk of any type of cancer and a decrease survival rate
Necessary for the maintenance of strong bones and healthy teeth and decrease the risk of major fractures in older adults
Helps with diabetes management and maintaining healthy insulin levels
Offers immune support as well as protection to the nervous system and the brain
Essential to the health of the lungs and cardiovascular system
Helps inhibit the development of cancer
Protects the heart from inflammation and high blood pressure
Helps reduce obesity as it decreases overall fat mass

Vitamin D: Reference Links

https://www.sciencedaily.com/releases/2008/11/081107143847.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337085/

https://link.springer.com/article/10.1007/s11845-020-02427-9

https://pubmed.ncbi.nlm.nih.gov/20219962/

https://www.mdpi.com/2072-6643/12/9/2757

https://www.mdpi.com/2072-6643/12/8/2488

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325172/

12.15 Vitamin D Receptor

Benefits of Vitamin K2

Reduces the risk of heart disease by assisting calcium metabolism to prevent calcium deposits in the arteries
Helps keep your blood not too thick and not too thin and aids in blood clotting to prevent non stop bleeding in injuries
Prevents hardening or calcification of your tissues, organs and blood vessels
Maximize bone mass and reduce the risk of osteoporosis and fractures
Improves nervous system as it protects neurons and oligodendrocytes from oxidative injury
Reduces inflammation and the consequences of autoimmune diseases such as multiple sclerosis

Vitamin K2: Reference Links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/

https://health.clevelandclinic.org/vitamin-k2

https://pubmed.ncbi.nlm.nih.gov/23633049/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600246/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483258/

Benefits of Zinc

An essential micronutrient for the metabolism of more than 300 enzymes
Plays a crucial part in cell growth and development, metabolism, cognitive, reproductive
Facilitates protein folding and helps regulate gene expression
Zinc is the gatekeeper to the immune system
Needed for proper human growth for child and during pregnancy
Helps reduce skin inflammation, heal wounds and overall skin health
Counteract the side effects of cancer therapy such as chemotherapy
Effective anti-cancer and tumor suppressors, both in vitro and in vivo
Zinc assist in immunomodulatory effects that helps the management of COVID-19
The chelation of zinc is a potential therapeutic approach in Alzheimer's disease

Zinc: Reference Links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820120/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748737/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539547/

Benefits of Selenium

An essential micronutrient for the metabolism of more than 300 enzymes
Plays a crucial part in cell growth and development, metabolism, cognitive, reproductive
An Element of Life Essential for Thyroid Function
Facilitates protein folding and helps regulate gene expression
Slowing the progression of age-related macular degeneration predominantly from the Age-Related Eye Disease
Helps reduce skin inflammation, heal wounds and overall skin health

Selenium: Reference Links

https://pubmed.ncbi.nlm.nih.gov/10963212/

https://www.sciencedaily.com/releases/2008/11/081107143847.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748737/

Andean Sacha inchi (Plukenetia volubilis L.) shell biomass as new biosorbents for Pb2+ and Cu2+ ions

This article highlights on using Sacha inchi shells, a waste product from agriculture, to remove lead and copper ions from water. The authors conducted experiments to identify the most effective conditions for using Sacha inchi shells for this purpose. The study revealed that the shells performed best at a pH of 3 for lead removal and a pH of 6 for copper removal. These findings suggest that Sacha inchi shells could be a promising new biosorbent for eliminating heavy metals from water.

Biological Activity of Sacha Inchi (Plukenetia volubilis Linneo) and Potential Uses in Human Health: A Review

In this article, it discusses the potential health benefits of consuming the various parts of the plant. The seeds are especially rich in essential fatty acids, which are important for human health. The oil extracted from the seeds is also high in antioxidants. Sacha inchi has traditionally been used as a food source in South America. More recently, it has gained popularity as a health food.

Sacha Inchi (Plukenetia Volubilis L.): recent insight on phytochemistry, pharmacology, organoleptic, safety and toxicity perspectives

This is an article about Sacha Inchi (SI), a plant native to the Amazon rainforest. It discusses the various uses of SI seeds and oil, both traditionally and commercially. SI is a source of essential fatty acids, protein, and other bioactive compounds. The seeds are traditionally consumed roasted or used topically to treat skin conditions. Commercially, SI oil is used in food, cosmetics, and pharmaceuticals. The article also details the cultivation requirements and challenges of SI.

Sacha Inchi Oil: Reference Links

https://www.researchgate.net/publication/353280137_Biological_Activity_of_Sacha_Inchi_Plukenetia_volubilis_Linneo_and_Potential_Uses_in_Human_Health_A_Review

https://www.sciencedirect.com/science/article/abs/pii/S0925857416302610

https://www.sciencedirect.com/science/article/abs/pii/S0308814618308525

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542186/#r30

https://pubmed.ncbi.nlm.nih.gov/26011096/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483583/

https://www.sciencedirect.com/science/article/abs/pii/S0925857416302610

https://my.clevelandclinic.org/health/drugs/24987-immunomodulators

Ambulay J.P., Rojas P.A., Timoteo O.S., Barreto T.V., Colarossi A. Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity. J. Funct.Foods. 2020;64

https://pubmed.ncbi.nlm.nih.gov/34731811/

https://www.verywellfit.com/the-benefits-of-sacha-inchi-89510

Bueso A., Rodriguez-Perez R., Rodriguez M., Dionicio J., Perez-Pimiento A., Caballero M.L. Occupational allergic rhinoconjunctivitis and bronchial asthma induced by Plukenetia volubilis seeds. Occup. Environ. Med. 2010;67:797–798

Sea Buckthorn Oil: Reference Links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217465/

https://pubmed.ncbi.nlm.nih.gov/27616182/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217465/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589177/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763470/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9920455/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438513/

Tocotrienols: Reference Links

Yap SP, Yuen KH. (2004). Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. Int JPharmaceutics, 281, 67-78.

Patel V, et al. (2012). Oral Tocotrienols are transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver

Disease Score in Patients. The Journal of Nutrition, 142 (3), 513-9.

Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020.

Meneilly GS, Tessier D. (2001). Diabetes in elderly adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(1), M5-M13.

Tan SMQ, et al. (2018). Tocotrienol-rich vitamin E from palm oil (Tocovid) and its effects in diabetes and diabetic nephropathy: a pilot phase II clinical trial. Nutrients, 10(9), 1315.

Tan GCJ, et al. (2019). Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa

randomized controlled trial. Therapeutic Advances in Endocrinology and Metabolism, 10.

Yau JWY, et al. (2012). Meta-Analysis for Eye Disease (META-EYE) Study Group. Global prevalence and major risk factors of diabetic

retinopathy. Diabetes Care 35, 556–564

Ng YT, et al. (2020). The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial. Nutrients, 12, 1522

https://en.wikipedia.org/wiki/Protein_isoform

https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/biof.1873

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